Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy

Figure 3

Structure of O-acetyl-GD2 CAR examples. (a) An O-acetyl-GD2-specific mAb derived scFv is linked through a spacer and a transmembrane domain to the T cell receptor (TCR) complex CD3ζ chain intracellular signaling domain. (b) Additional costimulatory endodomains are shown in 2nd- and 3rd-generation CARs derived from CD28 or CD28 and 41BB, respectively. 41BB may be exchanged to other domains such as OX40 or ICOS.

(a)

(b)