(i) Disappearance of all enhancing disease for ≥4 weeks AND (ii) No new lesions AND (iii) Stable/improved T2/FLAIR AND (iv) No more than physiologic steroids AND (v) Stable/improved clinically
Partial response (PR)
(i) ≥50% ↓ sum of biperpendicular diameters of enhancing disease for ≥4 weeks AND (ii) No new lesions AND (iii) Stable/improved T2/FLAIR AND (iv) Stable/improved steroids AND (v) Stable/improved clinically
Stable disease (SD)
(i) Does not qualify for CR, PR, and PD AND (ii) No new lesions AND (iii) Stable/improved T2/FLAIR AND (iv) Stable/improved steroids AND (v) Stable/improved clinically
Progressive disease (PD)
(i) ≥25% ↑ sum of biperpendicular diameters of enhancing disease OR (ii) New lesions OR (iii) Significant worsened T2/FLAIR OR (iv) Significant clinical decline
iRANO criteria
If ≤6 months after start of IT
If >6 months after start of IT
Is a repeat scan required to confirm radiographic PD for patients without significant clinical decline?
Yes
No
Minimal time interval for confirmation of progression for patients without significant clinical decline
≥3 months
Not applicable
Is further immunotherapy (IT) treatment allowed after initial radiographic PD (if clinically stable) pending progression confirmation?
