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Journal of Immunology Research
Volume 2017, Article ID 7047201, 11 pages
https://doi.org/10.1155/2017/7047201
Research Article

Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis

1Department of Immunology, China Medical University, Shenyang 110122, China
2Department of Immunology, College of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China

Correspondence should be addressed to Changlong Lu; moc.qq@502392268

Received 16 November 2016; Accepted 9 March 2017; Published 11 May 2017

Academic Editor: Kurt Blaser

Copyright © 2017 Fangli Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood. Methods. We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge. Results. DSS-resistant BALB/c mice were characterized by low levels of IFN-γ and TNF-α but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN) CD4+CD25+FoxP3+ T cells when compared to C57BL/6 mice. Collectively, these data indicate the propensity of BALB/c mice towards a Th2/Th17/Treg-polarized immunity protecting these animals against DSS challenge, whereas Th1-polarization of C57BL/6 mice confers sensitivity to DSS-induced colitis. Conclusions. The intrinsic congenital capacity of mouse strains with respect to T cell proliferation determines sensitivity to experimental colitis.