Passive Immunoprophylaxis for the Protection of the Mother and Her Baby: Insights from In Vivo Models of Antibody Transport

Figure 2

Pharmacokinetic (PK) parameters of a hepatitis B immune globulin (HBIG) product in pregnant and nonpregnant guinea pigs. Human IgG has larger clearance (a), lower mean residence time (MRT, (b)), larger volume of distribution at steady state (, (c)), and lower half-life (d) when it is administered at the end of gestation () compared to nonpregnant animals; data shown as mean ± SEM, (Student’s t-test).

(a)

(b)

(c)

(d)