Polymorphism rs2073618 of the TNFRSF11B (OPG) Gene and Bone Mineral Density in Mexican Women with Rheumatoid Arthritis
Table 3
Evaluation of the rs2073618 polymorphism as a predictor of low bone mineral density (BMD) in patients with rheumatoid arthritis (RA).
Rheumatoid arthritis ()
Low BMD ()
Normal BMD ()
OR
95% CI
Genotype
GG, (%)
93 (71.0)
29 (64.4)
—
—
GC, (%)
34 (26.0)
15 (33.3)
—
—
0.62
CC, (%)
4 (3.0)
1 (2.2)
—
—
GG versus GC (as a referent)
—
—
1.41
0.68 to 2.95
0.18
GG versus CC (as a referent)
—
—
0.80
0.09 to 7.46
0.46
GC versus CC (as a referent)
—
—
0.57
0.02 to 5.00
0.35
GC versus GG (as a referent)
—
—
0.71
0.34 to 1.48
0.18
CC versus GG (as a referent)
—
—
1.25
0.03 to 11.6
0.46
CC versus GC (as a referent)
—
—
1.76
0.18 to 17.1
0.34
Genetic models
Dominant model (GG versus CC + GC)
—
—
1.35
0.66 to 2.77
0.21
Recessive model (GG + GC versus CC)
—
—
0.72
0.07 to 6.63
0.42
Alleles, 2n = 352
2n = 262
2n = 90
G allele, 2n = 293 (%)
220 (84.0)
73 (81.1)
1.22
0.65 to 2.27
0.26
C allele, 2n = 59 (%)
42 (16.0)
17 (18.9)
0.82
0.44 to 1.53
0.26
RA: rheumatoid arthritis; BMD: bone mineral density; GG: homozygote genotype; GC: heterozygote genotype; CC: polymorphic homozygote genotype; OR: odds ratio risk; 95% CI: 95% confidence interval. p values were obtained comparing low BMD versus normal BMD. Low BMD was defined as osteopenia or osteoporosis (OP) (T-score ≤ 1 SD).
