Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice

<div>Dual TLR2/7 ligands induce limited mast cell activation directly but suppress IgE-and-antigen-induced mast cell degranulation. IL-6 secretion and cytotoxicity of stimulated BALB/c (a) and C57BL/6 (b) BMCMCs. TLR2/7 ligand-induced degranulation in the presence or absence of DNP-HSA from <i>α</i>DNP-IgE-sensitized C57.1 MCs. Dashed line indicates the level of <i>β</i>-hexosaminidase release induced by stimulation with 10 ng/mL DNP-HSA alone (c). Analysis of phospho-ERK1/2 (Thr202/Tyr204) levels in C57BL/6 BMCMCs stimulated with 5 <i>μ</i>M of the different TLR ligands for 5 min (d). 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Journal of Immunology Research

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Figure 3

Figure 3: Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice 