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Journal of Immunology Research
Volume 2017, Article ID 8394593, 10 pages
Research Article

Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status

1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany
2Department of Pathology, Klinikum Bayreuth, Bayreuth, Germany
3Private Practice for Gastroenterology, Alexanderstr. 2, 95444 Bayreuth, Germany
4Mikrogen GmbH, Neuried, Germany
5Department of Gastroenterology, Hepatology and Gastrointestinal Oncology, Bogenhausen Academic Teaching Hospital, Munich, Germany
6Institute for Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany
7Erasmus MC University Medical Center, Gastroenterology and Hepatology Rotterdam, Rotterdam, Netherlands
8Private Practice for Gastroenterology, Einsteinstraße 1, 81675 Munich, Germany
9DZIF German Centre for Infection Research, Munich, Germany

Correspondence should be addressed to Markus Gerhard; ed.mut@drahreg.sukram

Received 6 November 2016; Revised 12 February 2017; Accepted 15 March 2017; Published 30 May 2017

Academic Editor: Kristen M. Kahle

Copyright © 2017 Luca Formichella et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1. Study Populations. Supplementary Figure 1. The result of five representative recomLine tests incubated with individual patient sera are shown (LHP13 − LHP17). The assignment of the bands is given in the cartoon above. The test score calculation is given beside the recomLine tests. LHP 16 shows only a CagA band and thus represents a typical test result for an eradicated patient. Supplementary Table 2. Cross Table Histology vs. Serology (recomLine). Supplementary Table 3. Association between gastritis parameters and single H. pylori antigen positivity. Supplementary Table 4. Association between most severe lesions and single antigen H. pylori positivity. Supplementary Figure 2. Antigen frequencies of H. pylori positive and eradicated patients CagA was significantly (p<0.01) more often positive in eradicated patients (86.3%) than in H. pylori positive patients (69.2%), while all other immune responses were lower in the eradicated cohort.

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