Increased Neutrophil Extracellular Trap Formation in Uremia Is Associated with Chronic Inflammation and Prevalent Coronary Artery Disease
Table 2
Comparisons of baseline characteristics according to median level of baseline NET in MHD patients.
Baseline NET (median 7767.6)
Variables
Total
<median level
≥median level
Age (years)
64.0 ± 13.0
62.4 ± 13.2
65.5 ± 13.0
0.35
Gender, male, n (%)
35 (58.3)
18 (62.1)
17 (54.8)
0.38
BMI
22.9 ± 4.4
22.6 ± 4.2
23.2 ± 4.6
0.61
Diabetes
35 (58.3)
17 (58.6)
18 (58.1)
0.59
Duration of dialysis (months)
49.4 ± 26.6
54.1 ± 25.2
41.9 ± 28.4
0.22
Systolic blood pressure (mmHg)
145.0 ± 19.8
141.9 ± 20.4
148.0 ± 19.4
0.24
Diastolic blood pressure (mmHg)
81.3 ± 10.7
79.0 ± 8.6
83.4 ± 12.2
0.11
Previous CAD, n (%)
19 (31.7)
4 (13.8)
15 (48.4)
0.004
Previous cerebrovascular accident, n (%)
9 (15.0)
2 (6.9)
7 (22.6)
0.08
WBC count (/μL)
6180 ± 1807
5622 ± 1896
6700 ± 1578
0.02
Neutrophil count (/μL)
4374 ± 1694
3482 ± 994
5302 ± 1777
<0.001
Lymphocyte count (/μL)
1271 ± 479
1370 ± 479
1168 ± 460
0.13
N/L ratio
4.2 ± 3.0
2.7 ± 0.9
5.8 ± 4.4
0.001
Hemoglobin (g/dL)
10.3 ± 0.9
10.5 ± 0.9
10.2 ± 0.9
0.14
Urea nitrogen (mg/dL)
52.6 ± 20.4
55.1 ± 22.3
50.3 ± 18.5
0.36
Creatinine (mg/dL)
8.2 ± 3.4
8.9 ± 3.5
7.6 ± 3.1
0.17
Albumin (g/dL)
3.6 ± 0.5
3.6 ± 0.6
3.6 ± 0.5
0.76
Uric acid (mg/dL)
6.9 ± 1.6
6.9 ± 1.9
6.8 ± 1.4
0.86
Cholesterol (mg/dL)
139.0 ± 28.7
145.9 ± 29.2
132.6 ± 27.7
0.07
hs-CRP (mg/L)
0.40 ± 1.13
0.03 ± 0.94
0.75 ± 1.20
0.01
Intact PTH (pg/mL)
181.5 ± 149.2
201.0 ± 158.8
163.1 ± 139.6
0.33
β2-microglobulin
22.9 ± 8.4
20.6 ± 5.8
25.7 ± 10.2
0.06
spKt/V
1.60 ± 0.28
1.57 ± 0.23
1.64 ± 0.33
0.42
Medications, %
Aspirin
56.8%
59.1%
55.5%
0.78
Lipid-lowering agent
35.0%
33.3%
37.1%
0.44
All data are expressed as mean ± SD except for those with which are expressed as median with range. BDI-II: Beck depression inventory II; BMI: body mass index; ESRD: end-stage renal disease; intact PTH: intact parathyroid hormone; TSH: thyroid-stimulating hormone; hs-CRP: high-sensitivity C-reactive protein; spKt/V: single pool Kt/V; nPCR: normalized protein catabolism rate.