Research Article

Increased Neutrophil Extracellular Trap Formation in Uremia Is Associated with Chronic Inflammation and Prevalent Coronary Artery Disease

Table 2

Comparisons of baseline characteristics according to median level of baseline NET in MHD patients.

Baseline NET (median 7767.6)
VariablesTotal<median level≥median level

Age (years)64.0 ± 13.062.4 ± 13.265.5 ± 13.00.35
Gender, male, n (%)35 (58.3)18 (62.1)17 (54.8)0.38
BMI22.9 ± 4.422.6 ± 4.223.2 ± 4.60.61
Diabetes35 (58.3)17 (58.6)18 (58.1)0.59
Duration of dialysis (months)49.4 ± 26.654.1 ± 25.241.9 ± 28.40.22
Systolic blood pressure (mmHg)145.0 ± 19.8141.9 ± 20.4148.0 ± 19.40.24
Diastolic blood pressure (mmHg)81.3 ± 10.779.0 ± 8.683.4 ± 12.20.11
Previous CAD, n (%)19 (31.7)4 (13.8)15 (48.4)0.004
Previous cerebrovascular accident, n (%)9 (15.0)2 (6.9)7 (22.6)0.08
WBC count (/μL)6180 ± 18075622 ± 18966700 ± 15780.02
Neutrophil count (/μL)4374 ± 16943482 ± 9945302 ± 1777<0.001
Lymphocyte count (/μL)1271 ± 4791370 ± 4791168 ± 4600.13
N/L ratio4.2 ± 3.02.7 ± 0.95.8 ± 4.40.001
Hemoglobin (g/dL)10.3 ± 0.910.5 ± 0.910.2 ± 0.90.14
Urea nitrogen (mg/dL)52.6 ± 20.455.1 ± 22.350.3 ± 18.50.36
Creatinine (mg/dL)8.2 ± 3.48.9 ± 3.57.6 ± 3.10.17
Albumin (g/dL)3.6 ± 0.53.6 ± 0.63.6 ± 0.50.76
Uric acid (mg/dL)6.9 ± 1.66.9 ± 1.96.8 ± 1.40.86
Cholesterol (mg/dL)139.0 ± 28.7145.9 ± 29.2132.6 ± 27.70.07
hs-CRP (mg/L)0.40 ± 1.130.03 ± 0.940.75 ± 1.200.01
Intact PTH (pg/mL)181.5 ± 149.2201.0 ± 158.8163.1 ± 139.60.33
β2-microglobulin22.9 ± 8.420.6 ± 5.825.7 ± 10.20.06
spKt/V1.60 ± 0.281.57 ± 0.231.64 ± 0.330.42
Medications, %
Aspirin56.8%59.1%55.5%0.78
Lipid-lowering agent35.0%33.3%37.1%0.44

All data are expressed as mean ± SD except for those with which are expressed as median with range.
BDI-II: Beck depression inventory II; BMI: body mass index; ESRD: end-stage renal disease; intact PTH: intact parathyroid hormone; TSH: thyroid-stimulating hormone; hs-CRP: high-sensitivity C-reactive protein; spKt/V: single pool Kt/V; nPCR: normalized protein catabolism rate.