Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge

Figure 4

Comparison of pulmonary gene expression profiles following a B. pertussis challenge in mice with different pertussis immunity background. Averaged fold changes of 27 clusters (A–AA) of infected nonimmunized mice and challenged mice with infection-induced immunity, omvPV-immunization, or wPV-immunization background are depicted in a time course. Additionally, six groups (I–VI) with similarity in function are shown. The moment at which the B. pertussis infection or challenge was performed is depicted as well as the log10 number of colony forming units (cfu) for each time point postchallenge as determined previously [7, 8].