Journal of Immunology Research / 2017 / Article / Tab 1 / Review Article
Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review Table 1 Overview of polymorphisms in genes encoding proinflammatory cytokines and association with cervical neoplasia risk.
Gene Cohort Cases Population Distribution Risk (OR, 95% CI); Reference IL1B c.-511C>T (rs16944) Cervical cancer 182 Korean Genotypes CT: 2.83 (1.52 –5.28); 44.8% TT: 1.68 (0.85–3.32)CT/TT: 2.42 (1.31 –4.46); 54.2% [12 ] 150 North Indian Alleles T: 1.83 (1.28 –2.61); 33.9% [13 ] Genotypes CT: 1.37 (0.59–3.20)TT: 2.77 (1.21 –6.41); 36.6% 404 Chinese Han Genotypes CT: 1.53 (1.09 –2.15); 19.5% TT: 1.47 (0.97–2.24)CT/TT: 1.52 (1.10 –2.09); 26.2% [14 ] 100 Egyptian Alleles T: 2.00 (1.19 –3.38); 37.5% [15 ] Genotypes CT: 0.72 (0.36–1.43)TT: 2.16 (1.07 –4.33); 30.6% CT/TT: 2.91 (1.01 –8.36); 61.0% 736 Asian Genotypes CT: 1.69 (1.29 –2.22) TT: 1.64 (1.19 –2.25) CT/TT: 1.69 (1.30 –2.18) [16 ] TNFA c.-308G>A (rs1800629) Cervical cancer 195 North Portuguese Genotypes GA: 1.81 (1.10 –2.97); 11.5% AA: 2.54 (0.65–10.52)GA/AA: 1.88 (1.20 –2.94); 13.7% [17 ] Cervical cancer 2279 Varied Alleles A: 1.57 (1.21 –2.04) [16 ] Cervical cancer + CIN 165 Indo-Aryan Alleles A: 2.70 (1.41 –5.15); 13.2% [18 ] IFNG c.+874T>A (rs2430561) Cervical cancer 200 North Indian Genotypes TA: 3.30 (2.05 –5.20); 43.6% AA: 1.90 (0.90–3.90)TA/AA: 2.90 (1.90 –4.60); 48.8% [19 ] 200 North Indian Alleles A: 1.54 (1.17 –2.03); 23.0% [20 ] Genotypes TA: 1.56 (0.88–2.78)AA: 2.43 (1.34 –4.42); 25.3% 186 Chinese Alleles A: 1.47 (1.10 –1.97); 17.6% [21 ] Genotypes TA: 1.58 (0.86–2.91)AA: 2.22 (1.19 –4.15); 24.0% 1116 Varied Genotypes TA/AA: 1.399 (1.097 –1.784) [22 ] 1532 Varied Alleles A: 1.30 (1.01 –1.69) [16 ]
n : number of cases; OR: odds ratio; 95% CI: 95% confidence interval; CIN: cervical intraepithelial neoplasia; PAF: population attributable fraction. variation and dbSNP reference number. relative to major allele or major allele homozygotes. listed if OR > 1.00. associations listed in bold.