Review Article

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review

Table 1

Overview of polymorphisms in genes encoding proinflammatory cytokines and association with cervical neoplasia risk.

GeneCohortCases PopulationDistributionRisk (OR, 95% CI); Reference

IL1Bc.-511C>T (rs16944)Cervical cancer182KoreanGenotypesCT: 2.83 (1.525.28); 44.8%
TT: 1.68 (0.85–3.32)
CT/TT: 2.42 (1.314.46); 54.2%
[12]
150North IndianAllelesT: 1.83 (1.282.61); 33.9%[13]
GenotypesCT: 1.37 (0.59–3.20)
TT: 2.77 (1.216.41); 36.6%
404Chinese HanGenotypesCT: 1.53 (1.092.15); 19.5%
TT: 1.47 (0.97–2.24)
CT/TT: 1.52 (1.102.09); 26.2%
[14]
100EgyptianAllelesT: 2.00 (1.193.38); 37.5%[15]
GenotypesCT: 0.72 (0.36–1.43)
TT: 2.16 (1.074.33); 30.6%
CT/TT: 2.91 (1.018.36); 61.0%
736AsianGenotypesCT: 1.69 (1.292.22)
TT: 1.64 (1.192.25)
CT/TT: 1.69 (1.302.18)
[16]

TNFAc.-308G>A (rs1800629)Cervical cancer195North PortugueseGenotypesGA: 1.81 (1.102.97); 11.5%
AA: 2.54 (0.65–10.52)
GA/AA: 1.88 (1.202.94); 13.7%
[17]
Cervical cancer2279VariedAllelesA: 1.57 (1.212.04)[16]
Cervical cancer + CIN165Indo-AryanAllelesA: 2.70 (1.415.15); 13.2%[18]

IFNGc.+874T>A (rs2430561)Cervical cancer200North IndianGenotypesTA: 3.30 (2.055.20); 43.6%
AA: 1.90 (0.90–3.90)
TA/AA: 2.90 (1.904.60); 48.8%
[19]
200North IndianAllelesA: 1.54 (1.172.03); 23.0%[20]
GenotypesTA: 1.56 (0.88–2.78)
AA: 2.43 (1.344.42); 25.3%
186ChineseAllelesA: 1.47 (1.101.97); 17.6%[21]
GenotypesTA: 1.58 (0.86–2.91)
AA: 2.22 (1.194.15); 24.0%
1116VariedGenotypesTA/AA: 1.399 (1.0971.784)[22]
1532VariedAllelesA: 1.30 (1.011.69)[16]

n: number of cases; OR: odds ratio; 95% CI: 95% confidence interval; CIN: cervical intraepithelial neoplasia; PAF: population attributable fraction.
variation and dbSNP reference number.
relative to major allele or major allele homozygotes.
listed if OR > 1.00.
associations listed in bold.