Review Article

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review

Table 3

Overview of polymorphisms in gene encoding chemokines and association with cervical neoplasia risk.

GeneCohortCases PopulationDistributionRisk (OR, 95% CI); Reference

CXCL12 (SDF-1)G>A rs266085Cervical cancer917AmericanAllelesA: 0.74 (0.560.98)[29]
Haplotypes (rs266085/ rs17885289G>A/ rs266093C>G)A/A/C: 0.69 (0.540.89)
348Han ChineseAllelesA: 1.41 (1.141.74); 17.1%[30]

n: number of cases; OR: odds ratio; 95% CI: 95% confidence interval.
variation and dbSNP reference number.
relative to major allele or major allele homozygotes.
listed if OR > 1.00.
associations listed in bold.