Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation

Figure 1

Schematic representation of CRBN-mediated function regulation. In the absence of immunomodulatory drugs (IMiDs), CRBN has an important role in the regulation of ion transport, modulation of AMP-activated protein kinase (AMPK) signaling, and metabolism in cell and whole tissues or organs. In the presence of IMiDs, CRBN is the target protein of IMiDs and helps exert their multiple functions.