Computational Approaches to Facilitate Epitope-Based HLA Matching in Solid Organ Transplantation

Figure 3

The reliability of the PIRCHE-II and eplet estimations in different settings. The percentage of typing with a delta of zero between the observed and the reference values was plotted for ln(PIRCHE-II) (a) and ln(eplet) (b). For both ln(PIRCHE-II) and ln(eplet), the percentage of typing with a delta of zero was diminished when HLA-C or HLA-DQ was omitted from the typing. The highest percentage was observed when using two-field HLA genotype data of the recipient and serological split level typing of the donor. The different percentiles observed in the different settings were plotted for ln(PIRCHE-II) (c) and for ln(eplet) (d). The dashed horizontal lines in (c) and (d) indicate a delta of zero.

(a)

(b)

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(d)