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Journal of Immunology Research
Volume 2017 (2017), Article ID 9363750, 15 pages
https://doi.org/10.1155/2017/9363750
Research Article

Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus

1Barcelona Institute for Global Health (ISGlobal), Centre for Research in International Health (CRESIB), Hospital Clinic-University of Barcelona, Barcelona, Spain
2Laboratory of Immunomedicine, Faculty of Medicine, University Complutense of Madrid, Ave Complutense S/N, 28040 Madrid, Spain

Correspondence should be addressed to Pedro A. Reche

Received 19 May 2017; Revised 7 August 2017; Accepted 20 August 2017; Published 28 September 2017

Academic Editor: Peirong Jiao

Copyright © 2017 Julio Alonso-Padilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Additional File S1. Experimentally determined EBV-specific T and B cell epitopes. EBV-specific epitopes are included in three tables: Table S1A (CD8 T cell epitopes), Table S1B (CD4 T cell epitopes) and Table S1C (B cell epitopes). Tables are depicted in three sheets of the excel file. Additional File S2. Conserved EBV-specific CD8 T, CD4 T and B cell epitopes. Conserved epitopes are included in three tables: Table S2A (Conserved EBV-specific CD8 T epitopes), Table S2B (Conserved EBV-specific CD4 T epitopes) and Table S2C (conserved EBV-specific B cell epitopes). Tables are depicted in three sheets of the excel file. Additional File S3. Figure S1. Structural mapping of experimental gb350 B cell epitopes that were discarded. Figure depicts the location in the relevant 3D-structure of conserved gb350 B cell epitopes that were discarded for epitope-vaccine design. Conserved EBV B cell epitopes SVKTEMLGNEID and QVSLESVDVYFQDVFGTMWC were discarded because mapped onto buried or semi-buried regions of gp350 (PDB code: 2H6O). The conserved EBV epitope TNTTDITYVGD was discarded because mapped onto a highly structured and rigid region. The gp350 3D-structure is shown as a pale green ribbon backbone but the epitopes that are shown as sticks. Figure was rendered using PyMOL.

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