Journal of Immunology Research / 2017 / Article / Tab 2 / Review Article
Neutrophils and Immunity: From Bactericidal Action to Being Conquered Table 2 Neutrophil antibacterial functions subverted by S. aureus . S. aureus produces a large suite of virulence factors to counteract specific neutrophil clearance mechanisms during the pathogenesis of invasive infection.
Virulence factor Targets Function Ref. SSL-5 PSGL1/GPCRs Recruitment/chemotaxis inhibition [47 , 48 ] SSl-6 PSGL1 Recruitment inhibition [49 ] SSl-11 PSGL1 Recruitment inhibition [50 ] SSl-3 TLR2 Chemotaxis inhibition [51 , 52 ] SEIX PSSG1 Recruitment inhibition [49 ] ScpA CXCR2 Chemotaxis inhibition [53 ] CHIPS FPR1, C5aR Chemotaxis inhibition [54 , 55 ] FLIPr FPR2 Chemotaxis inhibition [56 , 57 ] FLIPrL FPR1, FPR2 Chemotaxis inhibition [56 , 57 ] PSMs FPR2 Chemotaxis inhibition/neutrophils lysis [56 , 58 ] Eap ICAM1/C4b/NE/CG/PR3 Recruitment/phagocytic inhibition [59 ] Aureolysin C3 Complement inhibition [60 ] SCIN C3bBb Complement inhibition [61 , 62 ] SCIN-B/C C3bBb Complement inhibition [61 , 62 ] Efb C3b Complement inhibition [63 ] Ecb C3b Complement inhibition [64 ] SSL7 IgA/C5 Phagocytosis/complement inhibition [65 ] SSL10 IgG Phagocytosis inhibition [66 ] SAK C3/IgG Phagocytosis inhibition [67 ] Sbi IgG/C3/factor H Phagocytosis inhibition [68 , 69 ] SpA IgG Phagocytosis inhibition [70 ] ClfA Factor I Phagocytosis inhibition [56 ] SOK Unknown Phagocytosis inhibition [71 ] CP Unknown Phagocytosis inhibition [72 ] SdrE Factor H Complement inhibition [73 ] IsdH C3b Complement inhibition [74 ] Cna C1q Complement inhibition [75 ] LukAB M integrinNeutrophils lysis [76 ] LukED CCR5/CXCR1/CXCR2 Neutrophils lysis [77 ] LukMF Not known Neutrophils lysis [78 ] PVL C5aR Neutrophils lysis [79 ] Hla C5aR Neutrophils lysis [80 ] Staphyloxanthin Unknown Resistance to ROS [81 ] KatA Hydrogen peroxide Resistance to ROS [82 ] AhpC Hydrogen peroxide Resistance to ROS [82 ] Msr Hydrogen peroxide Resistance to ROS [83 ] AdsA Adenosine Resistance to ROS [84 ] IsdA Fibrinogen Resistance to lactoferrin [85 ] OatA Peptidoglycan Resistance to lysozyme [86 , 87 ] EapH1 NSPs Resistance to NSPs [88 ] EapH2 NSPs Resistance to NSPs [88 ] Nuclease DNA Resistance to NETs [89 ]