Research Article

Serum Cytokine Levels and Their Relation to Clinical Features in Patients with Autoimmune Liver Diseases

Table 4

Spearman rank correlations between laboratory variables and serum cytokine levels measured. Numbers given are values. Statistically significant correlations are marked with italic font.

Total bilirubinESRASTAlkPAlbuminγ-Globulin

AILD
IL-2−0.28 (0.034)0.03 (0.84)−0.17 (0.21)−0.16 (0.27)0.07 (0.67)0.09 (0.57)
IL-4−0.04 (0.75)0.16 (0.25)−0.04 (0.80)0.07 (0.65)0.14 (0.37)−0.04 (0.80)
IL-60.23 (0.08)0.10 (0.46)0.02 (0.88)−0.12 (0.43)−0.30 (0.044)0.25 (0.10)
IL-80.42 (0.001)0.41 (0.002)0.32 (0.018)0.45 (0.001)−0.33 (0.026)0.18 (0.23)
TNF-α0.18 (0.17)−0.07 (0.59)0.11 (0.44)0.12 (0.40)−0.13 (0.41)0.08 (0.61)

AIH
IL-2−0.25 (0.18)−0.13 (0.50)−0.37 (0.052)−0.18 (0.39)0.13 (0.53)−0.06 (0.79)
IL-4−0.21 (0.27)−0.14 (0.47)−0.14 (0.48)−0.45 (0.023)0.26 (0.20)−0.07 (0.72)
IL-60.24 (0.20)0.02 (0.90)0.20 (0.30)0.22 (0.29)−0.29 (0.15)0.02 (0.92)
IL-80.43 (0.017)0.32 (0.09)0.40 (0.032)0.37 (0.07)−0.32 (0.11)0.20 (0.32)
TNF-α−0.09 (0.63)−0.36 (0.05)0.05 (0.79)0.03 (0.90)−0.14 (0.50)0.15 (0.47)

Overlap syndrome
IL-2−0.33 (0.08)0.38 (0.07)−0.03 (0.87)−0.19 (0.38)0.05 (0.86)0.11 (0.65)
IL-40.21 (0.28)0.31 (0.14)−0.07 (0.74)−0.01 (0.97)−0.12 (0.62)0.20 (0.41)
IL-60.27 (0.16)0.49 (0.014)−0.09 (0.67)−0.20 (0.36)−0.39 (0.10)0.46 (0.046)
IL-80.34 (0.08)0.27 (0.19)0.09 (0.66)0.19 (0.37)−0.41 (0.08)0.25 (0.31)
TNF-α0.56 (0.002)0.28 (0.17)0.22 (0.27)0.21 (0.32)−0.12 (0.62)0.09 (0.90)

AILD: autoimmune liver disease; AIH: autoimmune hepatitis; IL: interleukin; TNF-α: tumour necrosis factor-alpha; ESR: erythrocyte sedimentation rate; AST: aspartate aminotransferase; AlkP: alkaline phosphatase.