Adrenomedullin Regulates IL-1β Gene Expression in F4/80+ Macrophages during Synovial Inflammation

Figure 5

Effects of adrenomedullin (AM) on interleukin- (IL-) 1β gene expression in cultured primary synovial fibroblasts and macrophages. The effects of AM on F4/80, IL-1β, AM, RAMP2, and RAMP3 gene expression in cultured primary synovial fibroblasts (F4/80-negative fraction) and macrophages (F4/80-positive fraction) were examined by real-time PCR. compared with F4/80-negative fraction. compared with fraction matched-untreated control.

(a) F4/80

(b) IL-1β

(c) AM

(d) RAMP2

(e) RAMP3