EGFR-Targeted Immunotoxin Exerts Antitumor Effects on Esophageal Cancers by Increasing ROS Accumulation and Inducing Apoptosis via Inhibition of the Nrf2-Keap1 Pathway

Figure 6

In vivo efficacy of PT in the KYSE-450 xenograft tumor model. (a) Mean tumor volumes of mice xenografted with KYSE-450 cells and treated with PT. There were 6 mice per treatment group. PT treatment started as indicated in the graphs (black arrows). Error bars show ±SD (). (b) Histological examination was conducted in nude mice post 2 weeks after the last injection with Pan or PT. Representative images (magnification, ×400) of the liver from nude mice injected with indicated agents for two times were obtained by staining with hematoxylin and eosin. Scale bars: 100 μm. (c) Effect of PT on nude mice body weight was determined using KYSE-450 tumor-bearing nude mice. Mice were weighed at regular intervals during the whole period to monitor therapy-related toxicity.

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