Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome

Table 4

Summary of putative DAMP/TLR interactions in SS.

DAMP	TLR	Refs
(i) Biglycan and decorin are degraded by saliva from NOD.B10 mice; (ii) Versican is increased in SGEC lines from SS patients	TLR2 and TLR4; TLR2/6 heterodimer	[95]; [108]
(i) Fibronectin is dysregulated in salivary tissue from SS mice and upregulated in saliva from SS patients; (ii) Calprotectin (S100A8/A9) levels are elevated in sera, salivary tissue, and saliva of pSS patients; (iii) MUC5B and MUC7 are mislocalized in the ECM of pSS patients	TLR4	[109]; [110]; [95]; [111]; [112]; [113]; [114]; [115]
(i) Long interspersed nuclear element 1 (LINE-1) is increased in MSG tissue from SS patients	TLR 7/8	[116]; [117]