Fn14 Deficiency Ameliorates Anti-dsDNA IgG-Induced Glomerular Damage in SCID Mice

<div>Renal fibrosis is reduced in Fn14-deficient kidneys. (a) Kidney sections were stained by trichrome. (b) The trichrome-stained sections were scored for glomerular fibrosis. (c) By real-time PCR, the mRNA levels of transforming growth factor-<i>β</i> (TGF-<i>β</i>), platelet-derived growth factor subunit B (PDGFB), connective tissue growth factor (CTGF), fibronectin 1, and collagen 1A1 were determined in kidneys of anti-dsDNA IgG hybridoma cell-injected mice. (d) By immunohistochemistry, PDGFB expression was detected in glomeruli. (e) The PDGFB-stained sections were scored semiquantitatively. There were eight mice in each group. Representative images are shown. Fn14: fibroblast growth factor-inducible 14. 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Journal of Immunology Research

fig4

Figure 4

Figure 4: Fn14 Deficiency Ameliorates Anti-dsDNA IgG-Induced Glomerular Damage in SCID Mice 