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Journal of Immunology Research
Volume 2018, Article ID 1264074, 8 pages
Review Article

Regulation of Immune Function by Polyphenols

College of Bioscience and Biotechnology, College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China

Correspondence should be addressed to Hongmei Jiang; nc.ude.uanuh@ncdnmhj and Jun Fang; nc.ude.uanuh@3791nujgnaf

Received 30 January 2018; Accepted 27 March 2018; Published 12 April 2018

Academic Editor: Kai Wang

Copyright © 2018 Sujuan Ding et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Immune dysfunction is caused by various factors, including changes in relevant immune regulators and environmental stress. Immune system imbalance leads to a variety of diseases in humans. Nutrition may play an essential role in immunity by interfering with proinflammatory cytokine synthesis, immune cell regulation, and gene expression. Polyphenols, one of many categories of natural substances, exhibit a range of biological activities. Polyphenols promote immunity to foreign pathogens via various pathways. Different immune cells express multiple types of polyphenol receptors that recognise and allow cellular uptake of polyphenols, which subsequently activate signalling pathways to initiate immune responses. Furthermore, the polyphenols curcumin and epigallocatechin gallate can induce epigenetic changes in cells. In summary, polyphenols can be used to regulate intestinal mucosal immune responses, allergic diseases, and antitumour immunity.