Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias

Figure 3

Comparison of CD68⁺ and CD163⁺ macrophage densities among the four groups. The numerical densities of CD68⁺ macrophages standardized by interstitial density [N_A(CD68)/N_A(int)] were significantly increased in IPF/UIP, NSIP, and COP relative to those in normal control lungs (a). The numerical densities of CD163 macrophages [N_A(CD163)/N_A(int)] were significantly increased in NSIP and COP relative to those in normal control lungs and IPF/UIP (b). The ratio of CD163⁺ macrophages to CD68⁺ macrophages was significantly increased in IPF/UIP and normal control lungs relative to those in the other 2 groups (c) [N_A(CD163)/N_A(CD68)]. The values of the numerical densities described in the figures represent actual values multiplied by 10³. , , and .

(a)

(b)

(c)