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Journal of Immunology Research
Volume 2018, Article ID 1943497, 13 pages
https://doi.org/10.1155/2018/1943497
Review Article

Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies

1Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China
2School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China
3Department of Intensive Care Unit, First Hospital of Jilin University, Changchun 130021, China
4Department of Interventional Therapy, First Hospital of Jilin University, Changchun 130021, China

Correspondence should be addressed to Jie Ma; nc.ude.ulj@eij_am and Fang Wang; nc.ude.ulj@fw

Received 20 October 2017; Revised 24 March 2018; Accepted 6 May 2018; Published 28 June 2018

Academic Editor: Hector Rodriguez Cetina Biefer

Copyright © 2018 Yuze Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma. These lay the foundations for targeted therapies in terms of direct and indirect immune regulators of lipid metabolism, which ultimately help provide effective control of obesity-related asthma with a feasible treatment strategy.