Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice

Figure 3

The frequency of CD4+Foxp3+ T_Reg cells reversibly increases in sepsis with SIRT1 inhibition. Cumulative results of CD4+Foxp3+ T_Reg cells presented as (a) frequency of CD4 (%) and (b) absolute cell count. Cumulative results of CD4+Foxp3+CTLA4+ T_Reg cells presented as (c) frequency of CD4 (%) and (d) absolute cell count. (e) Representative figure of the ratio changes in population size of CD4+ T cells and CD4+ T_Reg subpopulation. Markers are not representative of surface versus intracellular location. Data are representative of three independent analyses with a total of 5 mice in each group. Data are expressed as mean ± SEM. mice/group. .

(a)

(b)

(c)

(d)

(e)