The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions

Figure 1

Time frame of detrimental factors leading to early injury and late loss of function after islet transplantation is shown. Massive tissue loss due to IBMIR early during transplantation reduces successful engraftment. Islets endure a severely hypoxic environment in the first several days and rely only on passive oxygen diffusion for survival.