Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization

Figure 7

VEGF production by NK cell subsets. Flow cytometric analysis on CD56^bright and CD56^dim NK cell subsets from healthy individuals (hPB), peripheral blood (iPB) and pleural effusion (iPE) from patients with inflammatory disease, peripheral blood (ptPB) and pleural effusion (ptPE) from patients with primary tumor, and peripheral blood (tmPB) and pleural effusion (tmPE) from patients with tumor metastasis revealed an increased production of VEGF in PE samples as compared with PB and healthy donors (a-b). Representative dot plots of VEGF production by CD56^bright and CD56^dim NK cell subsets from healthy donors and patients with inflammatory, primary, and metastatic tumor PE are shown, respectively (b). Data are shown as mean ± SEM of 34 samples; and ( values are shown).

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