Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response

Figure 1

Inflammation pathways induced by lipid. Lipid can be recognized by multiple molecules resident in cellular membrane, such as TLRs, NLRs, and CD1, to activate different signal pathways and ultimately induce inflammation. TLRs are responsible for IKKβ/NF-κB and ER stress augment, while NLRs activate Caspase1 expression and induce ROS production. Besides, lipid captured by CD1 can be presented to T lymphocytes directly. All these signals participate in translating lipids to inflammatory response.