An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study
Table 3
HLA-B allele frequencies in patients with influenza A/H1N1 infection (INF-P) and asymptomatic healthy contacts (INF-C).
HLA-B
INF-P
INF-C
pC
OR
95% CI
AF
(%)
AF
(%)
B35:01:01
37
0.1341
13.406
64
0.1422
14.222
B15:01:01
26
0.0942
9.420
33
0.0733
7.333
B07:02:01
17
0.0616
6.159
24
0.0533
5.333
B48:01:01
17
0.0616
6.159
20
0.0444
4.444
B39:06:02
15
0.0543
5.435
10
0.0222
2.222
2.5287
(1.1197–5.7111)
B40:02:01
14
0.0507
5.073
26
0.0578
5.778
B51:01:05
11
0.0399
3.986
3
0.0067
0.667
6.1849
(1.7100–22.3706)
B44:03:01
10
0.0362
3.623
3
0.0067
0.667
5.6015
(1.5279–20.5356)
B52:01:02
10
0.0362
3.623
15
0.0333
3.333
B39:05:01
9
0.0326
3.261
8
0.0178
1.778
B51:01:01
9
0.0326
3.261
33
0.0733
7.333
0.4259
(0.2006–0.9043)
B08:01:01
8
0.0290
2.899
10
0.0222
2.222
B14:02:01
7
0.0254
2.536
11
0.0244
2.444
B39:01:01
6
0.0217
2.174
36
0.0800
8.000
0.2556
(0.1062–0.6147)
B58:01:01
6
0.0217
2.174
3
0.0067
0.667
B73:01
6
0.0217
2.174
1
0.0022
0.222
9.9778
(1.1948–83.3273)
B13:02:01
5
0.0181
1.812
4
0.0089
0.889
B18:01:01
5
0.0181
1.812
9
0.0200
2.000
B35:17
5
0.0181
1.812
4
0.0089
0.889
B38:01:01
4
0.0145
1.449
6
0.0133
1.333
B40:05
4
0.0145
1.449
1
0.0022
0.222
B44:02:01
4
0.0145
1.449
16
0.0356
3.556
B49:01:01
4
0.0145
1.449
7
0.0156
1.556
B14:06:02
3
0.0109
1.087
B15:03:01
3
0.0109
1.087
5
0.0111
1.111
B35:02:01
3
0.0109
1.087
6
0.0133
1.333
B39:06:01
3
0.0109
1.087
6
0.0133
1.333
B40:01:01
3
0.0109
1.087
7
0.0156
1.556
B14:01:01
2
0.0072
0.725
4
0.0089
0.889
B27:03
2
0.0072
0.725
6
0.0133
1.333
B27:05:02
2
0.0072
0.725
2
0.0044
0.444
B35:05:01
2
0.0072
0.725
0
B35:12:01
2
0.0072
0.725
9
0.0200
2.000
B39:02:02
2
0.0072
0.725
3
0.0067
0.667
B41:01:01
2
0.0072
0.725
4
0.0089
0.889
B53:01:01
2
0.0072
0.725
2
0.0044
0.444
B15:02:01
1
0.0036
0.362
4
0.0089
0.889
B15:16:01
1
0.0036
0.362
0
B35:01:02
1
0.0036
0.362
0
B45:01:01
1
0.0036
0.362
5
0.0111
1.111
B57:01:01
1
0.0036
0.362
6
0.0133
1.333
B78:02:02
1
0.0036
0.362
0
B13:01:01
0
1
0.0022
0.222
B15:05:01
0
1
0.0022
0.222
B15:15
0
2
0.0044
0.444
B35:01:04
0
1
0.0022
0.222
B35:40N
0
1
0.0022
0.222
B37:01:01
0
1
0.0022
0.222
B38:01:02
0
6
0.0133
1.333
B40:01:02
0
1
0.0022
0.222
B40:01:04
0
3
0.0067
0.667
B40:02:03
0
1
0.0022
0.222
B40:11:01
0
1
0.0022
0.222
B42:01:01
0
2
0.0044
0.444
B44:18:01
0
1
0.0022
0.222
B45:01
0
1
0.0022
0.222
B46:02
0
1
0.0022
0.222
B50:01:01
0
3
0.0067
0.667
B51:02:01
0
1
0.0022
0.222
B55:01:01
0
3
0.0067
0.667
B55:02:01
0
2
0.0044
0.444
B56:01:01
0
1
0.0022
0.222
INF-P: influenza patients; INF-C: influenza contacts; HLA: human leukocyte antigen; AF: allele frequency; : number of subjects; OR: odds ratio; CI: confidence interval; pC: value after Bonferroni correction; only showing value < 0.05, which is considered significant.
