An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study

Table 5

HLA-A-B-C, A-B, B-C, and A-C haplotype frequencies in patients with influenza A/H1N1 infection (INF-P) and asymptomatic healthy contacts (INF-C).

Haplotype	INF-P		INF-C			pC	OR	95% CI
	HF	%	HF	%
A02:01:01-B35:01:01-C04:01:01	0.004	0.36	0.026	2.57			0.13	0.01–0.91
A24:02:01-B35:01:01	0.012	1.23	0.046	4.59			0.22	0.06–0.74
B35:01:01-C07:02:01	0.035	3.54	0.002	0.23			16.88	2.14–132.60
B39:01:01-C07:02:01	0.006	0.63	0.042	4.22			0.17	0.04–0.71
B40:02:01-C03:04:01	0.004	0.36	0.042	4.21			0.08	0.01–0.62
A68:01:02-C07:02:01	0.05	4.96	0.002	0.22			23.99	3.14–183.51

Haplotypes with uncorrected value < 0.05, which is considered significant, are only presented. All values were obtained by Fisher exact two-tailed test. INF-P: influenza patients; INF-C: influenza contacts; HF: haplotype frequency; : number of subjects; OR: odds ratio; CI: confidence interval; pC: value after Bonferroni correction. For a complete list of haplotypes, check Tables SIX–SXII.