Downregulation of iNOS, IL-1<i>β</i>, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats

<div>Expression of tryptase (AA1) and its colocalization with PAR4, iNOS, and P2X7 in the colonic mucosae of the visceral hyperalgesia rats. (a–c) Representative immunostainings for tryptase- (AA1-) positive MCs in the colonic sections are shown. The colonic sections were counterstained with toluidine blue. (d–f) Colonic sections from the visceral hyperalgesia rats costained with tryptase (AA1) and PAR4, iNOS, or P2X7 antibodies showing that the majority of the tryptase-positive MCs expressed PAR4, iNOS, or P2X7 (bar 100 <i>μ</i>m).</div>

Journal of Immunology Research

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Figure 2

Figure 2: Downregulation of iNOS, IL-1<i>β</i>, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats 

Figure 2 | Downregulation of iNOS, IL-1β, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats 