Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune Responses in Mice

<div>IgG and IgA antibodies in cells from mesenteric lymph nodes after IM immunization with 0.3 <i>μ</i>g of NoV GII.4 VLPs formulated with Al(OH)<sub>3</sub> (a) or MPLA (b). End-point titration curves of anti-GII.4 IgG and IgA antibodies in cell culture supernatants from pooled mesenteric lymph nodes (MLNs) of experimental groups stimulated <i>in vitro</i> with 5 <i>μ</i>g GII.4 VLPs. Control mice received PBS only.</div>

Journal of Immunology Research

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Figure 5

Figure 5: Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune Responses in Mice 

Figure 5 | Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune Responses in Mice 