TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling

Figure 2

IL-23/Th17 axis of psoriasis. Proposed paracrine signaling with TNIP1 regulation in psoriasis where nonimmune cells are keratinocytes [111]. We would suggest that variations of this could be relevant for SLE and SSc, where the nonimmune cells are a podocyte or fibroblast, respectively. For instance, following TLR7 or 9 activation of APCs in SLE, paracrine signaling would include type I interferons.