CD4^hiCD8^low Double-Positive T Cells Are Associated with Graft Rejection in a Nonhuman Primate Model of Islet Transplantation

Figure 2

Percentage of DP T cells in peripheral blood and tissues isolated from rhesus monkeys. (a) The percentage of CD4, CD8, and DP T cells in the peripheral blood (; aged between 48 and 72 months) and (b) the percentage of DP T cells in the peripheral blood mononuclear cell population, spleen, MLNs, and liver (; aged between 48 and 54 months) of rhesus monkeys. (c and d) Phenotypic characterization of T cell subsets in peripheral blood and tissues from rhesus monkeys using antibodies specific for CD28 and CD95. Data are expressed as the mean ± SD. PBMC: peripheral blood mononuclear cells; MLNs: mesenteric lymph nodes; TN: naïve T cells; TCM: central memory T cells; TEM: effector memory T cells.

(a)

(b)

(c)

(d)