CD4^hiCD8^low Double-Positive T Cells Are Associated with Graft Rejection in a Nonhuman Primate Model of Islet Transplantation

Figure 4

The number of peripheral DP T cells increased significantly in monkeys that rejected islet cell transplants. (a) The number of DP T cells in the peripheral blood of monkeys in which transplants survived did not change markedly (; aged between 54 and 72 months). (b) The number of DP T cells in the peripheral blood of monkeys that rejected the islet grafts increased significantly when compared with pretransplant levels (; aged between 54 and 72 months). BGL: blood glucose. Rm01, Rm02, Rm03, Rm04, Rm05, and Rm06 received islet xenografts, and Rm07 and Rm08 received allografts.

(a)

(b)