Prevention of Cyclophosphamide-Induced Immunosuppression in Mice with the Antimicrobial Peptide Sublancin

Figure 1

Effect of oral administration of sublancin on the phagocytic activity (a) and gene expression of cytokines (b–d) in P-Mac ex vivo. Six-week-old female BALB/c mice were separated into five groups and orally administered with sublancin (0.5, 1.0, and 2.0 mg/kg body weight/day) or 2.5 mg/kg levamisole hydrochloride (positive control) for 7 days. The vehicle control group was administered with distilled water daily. Mouse P-Mac were isolated and cultured in 10% FBS DMEM. After cultivation, the cells were used to analyze the phagocytic activity and gene expression of cytokines, respectively. Values are expressed as means ± SEM (); , , and compared with vehicle control group.

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