Research Article

M1-Polarized Macrophages Promote Self-Renewing Phenotype of Hepatic Progenitor Cells with Jagged1-Notch Signalling Involved: Relevance in Primary Sclerosing Cholangitis

Figure 1

Induction of BMDM polarization towards M1 or M2 phenotype in vitro. (a) Quantitative analysis of M1 macrophage-associated marker (Il1β, Il6, nos2, Tnfα, Ccl3, and Ccl4) and M2 macrophage-associated marker (Arg1, Mgl1, Chil3, Cd163, Clec7a, and Retnlα) expression in M0, M1, and M2 macrophages. (b) Membranous expressions of CD86 and CD206 levels on M0, M1, and M2 macrophages were determined by flow cytometry. The histogram is presented. vs M0 macrophages, vs M2 macrophages.
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