Review Article
The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases
Table 1
Ectonucleotidases (E-NTPDase, E-5
-nucleotidase, and ADA) and purinergic receptors in experimental models and patients with atherosclerosis.
| Sample | E-NTPDase | E-5-nucleotidase | Adenosine deaminase | Involved receptors | Reference |
| Endothelial cells and thoracic aorta from mouse model of atherosclerosis | ↓ enzymatic activity and expression | — | — | — | [72, 84] |
| ApoE-deficient mice | — | ↓ enzymatic activity and expression | — | — | [88] |
| Platelets and plasma from patients | ↓ enzymatic activity | ↑ enzymatic activity | — | — | [90] |
| Plasma of experimental model | — | — | ↑ enzymatic activity | A1 upregulation | [93] |
| Atherosclerotic vessel wall from aortoiliac bifurcation of Apoliprotein E- and LDL-deficient animals | — | — | ↓ enzymatic activity | — | [92] |
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