Review Article

The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases

Table 1

Ectonucleotidases (E-NTPDase, E-5-nucleotidase, and ADA) and purinergic receptors in experimental models and patients with atherosclerosis.

SampleE-NTPDaseE-5-nucleotidaseAdenosine deaminaseInvolved receptorsReference

Endothelial cells and thoracic aorta from mouse model of atherosclerosis↓ enzymatic activity and expression[72, 84]

ApoE-deficient mice↓ enzymatic activity and expression[88]

Platelets and plasma from patients↓ enzymatic activity↑ enzymatic activity[90]

Plasma of experimental model↑ enzymatic activityA1 upregulation[93]

Atherosclerotic vessel wall from aortoiliac bifurcation of Apoliprotein E- and LDL-deficient animals↓ enzymatic activity[92]