A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma

Table 3

Univariate and multivariate Cox regression analyses of prognostic factors for time to recurrence (TTR).

Variables	Univariate analyses		Multivariate analyses
	HR (95% CI)	value	HR (95% CI)	value
Gender
Male	1.319 (0.806–2.160)	0.271
Female
Age (years)
>50	0.705 (0.49–1.014)	0.06
≤50
HBs antigen
(+)	0.728 (0.440–1.203)	0.215
(−)
Cirrhosis
Yes	1.160 (0.740–1.819)	0.517
No
AFP (μg/L)
>20	1.510 (1.012–2.254)	0.044
≤20
Tumor size (cm)
>5	1.822 (1.245–2.666)	0.002
≤5
Tumor encapsulation
Complete	1.556 (1.076–2.248)	0.019
None
Microvascular invasion
Yes	2.104 (1.442–3.072)	<0.001	1.584 (1.037–2.421)	0.033
No
Tumor differentiation
I-II	2.326 (1.529–3.539)	<0.001	1.718 (1.081–2.730)	0.022
III-IV
BCLC stage
0 + A	2.034 (1.269–3.261)	0.003
B + C
Fib/Alb ratio
>0.062	1.704 (1.142–2.543)	0.009	1.555 (1.031–2.346)	0.035
≤0.062
ALBI grade
1	1.131 (0.783–1.632)	0.512
2 + 3
NLR
≥2.81	1.723 (1.177–2.523)	0.005
<2.81
PLR
≥115	1.466 (1.013–2.121)	0.043
<115

HR: hazard ratio; 95% CI: 95% confidence interval; BCLC: Barcelona Clinic Liver Cancer. Cox regression analysis, .