Research Article

Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer

Table 2

The DEGs in GEO data were identified in BC samples.

Gene names

Upregulated DEGsMAN1A1, ARHGDIB, PDE1A, SLC1A1, RNF182, CXCL1, ABLIM1, NEFL, GRAMD3, GJA1, TENM2, CFH, BDKRB1, CA8, HAS2, PTCHD1, STC1, NECTIN3, DNER, MARCKS, TRIM6, SYTL2, ARL4C, WNT5A, VCAM1, VEGFC, KLF12, NLGN1, LMO4, TNS3, ATXN1, LRRC15, CLEC2B, HHIP, TMEM45A, DAPK1, EPB41L3, ADGRG6, ENPP2, MLPH, TUBAL3, RUNX2, TMEM200A, EDN1, PAG1, DIXDC1, TCF4, IL1RAPL1, INHBB, ADAM12, EPS8, CNTN1, MYLK, G0S2, EFNA5, TMEM56, MMP2, TBC1D4, SLC16A2, LOXL2, RORA, SLC8A1, GDA, PAQR5, BHLHE41, RCAN3, ADAMTS5, TMEM158, ADAMTS12, DDIT4, DPP7, SNAI2, TENM3, C4orf47, PPARG, DPYSL2, PID1, C15orf48, CXCL3, CLU, FYN, PTGER4, TMPRSS15, CA12, CXCL8, BNIP3L, TFPI2, FBXL7, LRFN5, CHST4 SH3RF3, PDK3, PLPP3, P4HA2, PGM5, TSC22D1, FAM102B, TMEM44, GABBR2, GUCY1A2, NR5A2, MID1, CCL2, AKR1C3, MAP3K7CL, PXDNL, GCNT1, VLDLR, C11orf96, LOC283352, RNASE4, BASP1, PHACTR1, TGFBI, KLF6, HMOX1, ANXA3, SAT1, SLC39A4, ID2, SSBP2, PRUNE2, SLC1A3, AFP, NR2F1-AS1, RGS4, ANG, NDRG1, SLC25A30, NRN1 PFKFB4, ST3GAL5, TSC22D3, PXK, PRKCDBP, MYBL1, TMCO3, CTSB, NREP, PRICKLE2, NKX3–1, PPM1E, MAP1B, CD99, ITGA4, DDR2, SDC2, TUBB2A, CELF2, KANK1, EYA1, CCDC134, ALDH3B1, DPYSL4, IER3, MAP4K4, ATP8B3, LIFR, ARFGEF3, FOSL2, CAV1, NANOS1, KCNN4, PPP1R16A, SAP30, EPAS1, KCTD21, PBX1, TLE4, MICAL3, SIM1, PMEPA1, TAF9B, SMAD6, JUND, PDGFC, FPR1, GYS1, LSS, MXI1, CCDC92, IDH2, RRAS, AAMDC, CXCL2, RIPK4, DPY19L2P2, PEG10, DHRS3, ALDH1A1, MICAL2, CXXC5, DKK3, SELENOM, TCF7L1, IRS1, RFX5, TMSB4X, DCAF6, PRR16 STXBP6, CERK, PTTG1IP, ELL2, LINC00643, LACTB, ZNF385D, LTBP1, CAT, P2RY8 SNAPC3, SYNC, IL31RA, FAM229B, 3\Mar, ATP2B4, RASSF2, DNAJB4, SLC39A10, CUEDC1 LINC00165, MTHFD2L, RIMS3, TXNDC16, C10orf10, NAT1, PLEKHG4, GLCCI1, PIK3R3, LOC286161, NID2, CXADR, TNC, TUBA1A, GSTM4, LOC100506844, OGFRL1, FDFT1, CACNA1A, HERPUD2, CD109, PNRC1, PLIN2, SEC22C, GRK5, DHCR7, RRAGA, KDM4C, DPYSL5, MRGPRX3, CDH2, FAM127B, ANKRD20A5P, FAM127A, IL11RA, PPP4R4, MME, MGST3, LOC101927752, FAM168A, CDYL2, PPP1R3C, ZNF827, CCBE1, MSMO1, TM4SF1, P3H2, NCAM2, YPEL5, PTPRS, INSIG1, CDC42EP3, TCFL5, IL1R1, PRICKLE1, LGALS1, CPEB2, LOC105371967, TRIQK, SCD, FAM134B, LPAR1, GFPT2, COL13A1, FAM133A, F2R, TUSC1, CA9, ENO2, VEGFA, PLAU, KIF3C, KATNAL1, OPTN, FABP4, PDE8A, LOC283140, ADD3, SQLE, COL18A1, INSIG2, TADA3, TMEM170B, ATL1, CCL7, IGSF3, NEURL1B, CHI3L2, COL6A2, CHKB, PAPPA, TGIF1, HTRA1, TBC1D8B, ASAH1, ABCC10, MSC-AS1, VMP1, LOC101927027, IL18, LPCAT2, MYO9A, FLI1, KLF13, HBP1, PRR34-AS1, DHCR24, MGLL, GLCE, CCNG2, TTC13, MOSPD2, LOC100506922, ROBO2, ZNF697, HDAC4, MLF1, CSMD3, CCNA1, SCO2, SLC25A1, BNC2, ZNF704, CD82, PICSAR, FOXP4-AS1, FAM110B, SPAG4, RECK, CLDN1, SH3PXD2A, SNTB1, IRF9, LACC1, EPHX1, WWC3, THAP8, RIMS2, SREBF2, TMOD2, ZNF365, ARHGAP28, COL5A1, IFT74, LOC100130987, LINC01279, SPRY1, PQLC2L, CADM1, C11orf80, MIR210HG, PPP1R13L, KIAA0895, NRP1, PLSCR4, HGSNAT, KRCC1, HIST1H2AC, GPR137C, TNFAIP8, IQGAP3, WIPF1, URB1-AS1, IL17RD, MBD5, REEP6, ANK2, PQLC3, DNAJC6.

Downregulated DEGsPTPRD, VCAN, HAPLN1, JPH1, DSP, CA2, ZNF804A, ETV1, MTUS1, GULP1, ZNF268, KIT, PLEKHA5, RBP7, VGLL3, AASS, DKK1, KRT8, CHSY3, PTN, SLC7A2, ADRB1, TGFA, HSPB8, ATP7B, PCDH19, SLC18B1, ESM1, MAGEC2, ARHGAP42, ZNF462, SLC16A7, TMEM5, SOCS2, SYBU, MFAP5, GPC4, KHDRBS3, CHMP4C, AMPH, ST8SIA4, RGS2, LINC01234, SLAIN1, KCNQ3, TMEM246, ST3GAL1, GHR, ZNF711, LAMA1, PLEKHG3, ITPR2, ZNF518B, DOCK4, WISP3, SERPINE2, NFXL1, PLCXD2, ZNF350, MLKL, DLL1, ZNF331, DMKN, FAM171B, RPS6KA6, PDGFRL, KIAA1551, ZDHHC15, MYH2, NCBP3, BRAP, SOX7, PELP1, IL4R, HPD, STAC, METTL7B, IFI44, APBB2, SPOUT1, ENDOD1, HBEGF, MPP5, ESF1, MCM9, JAG1, SERPINB7, CYB5R2, MATR3, ANO5, CTNS, MOB3B, GFRA1, CCDC181, KIAA1671, EBI3, BEX5, KBTBD8, CD163L1, CASP4, LOC729732, RRAGD, CPNE8, ANKRD1, ITGA2, STK38L, TSR1, DGKI, TEX10, SWI5, HRK, TOX2, ZNF547, ZNF615, LOC400043, INTS6, CKB, GBP3, CCDC3, PRKAR2B, MBOAT1, ZNF708, RBBP6, SH3GL3, IL13RA1, PSMB8, ITGBL1, CEP126, RAP1GAP2, GLT8D2, ZNF605, CEP290, IL15RA, ZNF107, ZNF286A, PREX1, RNF125, SP110, ZNF267, PKP2, C11orf70, LIMCH1, NAV3, MBNL3, AKAP9, TMEM156, EHD1, MAP3K14, TBC1D30, CCDC85C, CHST2, LMO2, INPP4B, TMEM133, ERVMER61–1, ZNF91, CDK9, ZNF492, HMGN5, SEMA3A, MANSC1, IGFBP2, ELOVL4, UPP1, RNF175, ASAP1-IT1, LY6K, SLC2A13, LOC100506691.