Research Article

Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer

Table 4

Top fifteen significant signaling pathways associated with DEGs in BC according to value.

IDTermCount valueGenes

hsa00100Steroid biosynthesis60.000342MSMO1, SQLE, DHCR7, LSS, FDFT1, DHCR24
hsa04514Cell adhesion molecules (CAMs)120.005828VCAM1, NCAM2, CADM1, CLDN1, NLGN1, CNTN1, CD99, VCAN, NECTIN3, ITGA4, CDH2, SDC2
hsa04540Gap junction90.007066ADRB1, TUBB2A, GUCY1A2, TUBAL3, GJA1, PDGFC, LPAR1, TUBA1A, ITPR2
hsa04060Cytokine-cytokine receptor interaction150.015894IL1R1, CCL2, IL18, LIFR, CXCL8, KIT, IL11RA, CCL7, VEGFC, IL4R, VEGFA, IL15RA, PDGFC, IL13RA1, GHR
hsa00910Nitrogen metabolism40.015944CA9, CA8, CA12, CA2
hsa05202Transcriptional misregulation in cancer120.019138EYA1, FLI1, ID2, LMO2, PPARG, CXCL8, CDK9, ETV1, PBX1, RUNX2, PLAU, MLF1
hsa04668TNF signaling pathway90.020338CXCL1, VCAM1, CCL2, CXCL3, EDN1, CXCL2, MLKL, MAP3K14, PIK3R3
hsa04974Protein digestion and absorption80.022588COL18A1, KCNN4, SLC8A1, COL13A1, COL6A2, MME, SLC1A1, COL5A1
hsa05412Arrhythmogenic right ventricular cardiomyopathy70.025957PKP2, GJA1, DSP, ITGA2, ITGA4, CDH2, TCF7L1
hsa04151PI3K-Akt signaling pathway190.028358TNC, ITGA2, LPAR1, KIT, ITGA4, IRS1, COL5A1, DDIT4, LAMA1, VEGFC, IL4R, VEGFA, GYS1, COL6A2, EFNA5, PDGFC, PIK3R3, GHR, F2R
hsa04510Focal adhesion130.033173CAV1, TNC, ITGA2, ITGA4, COL5A1, VEGFC, LAMA1, FYN, VEGFA, COL6A2, PDGFC, PIK3R3, MYLK
hsa04150mTOR signaling pathway60.037778RPS6KA6, RRAGA, RRAGD, PIK3R3, IRS1, DDIT4
hsa05219Bladder cancer50.041527VEGFA, CXCL8, HBEGF, MMP2, DAPK1
hsa05200Pathways in cancer200.047909WNT5A, EPAS1, PTGER4, PPARG, CXCL8, ITGA2, BDKRB1, LPAR1, KIT, MMP2, TCF7L1, DAPK1, LAMA1, VEGFC, VEGFA, TGFA, NKX3-1, HHIP, PIK3R3, F2R
hsa04630Jak-STAT signaling pathway90.048544IRF9, SOCS2, IL4R, LIFR, IL15RA, PIK3R3, IL13RA1, IL11RA, GHR

The bold represented the key genes in the modules.