Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy

Figure 4

IL-22-FP promotes liver regeneration in a CCl4 model after PHx. Male C57BL/6 mice (8 to 10 wk old) were randomly divided into four groups: the CCl4 group, PHx group, CCl4 + PHx group, and CCl4 + PHx + IL-22-FP group. Mice in different groups were treated as described in Materials and Methods. (a) Liver weight/body weight ratios of different group mice at 32 h, 40 h, 48 h, and 1 wk post-PHx; for each group. (b) BrdU staining of residual liver in four groups of mice at 32, 40, and 48 h post-PHx (400x magnification). (c) BrdU⁺ hepatocyte/total hepatocyte ratios of four groups at different time points (32, 40, and 48 h) post-PHx. Pictures were taken at 400x magnification; for each group. and .

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