B Cell Activating Factor, Renal Allograft Antibody-Mediated Rejection, and Long-Term Outcome

Figure 1

BAFF, APRIL, and their receptors; BAFF binds with high affinity to both BAFF-R and TACI but with weak affinity to BCMA; APRIL conversely binds TACI and BCMA but does not bind BAFF-R. BAFF-R ligation primarily results in the activation of the nonclassincal NF-κB2 pathway, whereas TACI or BCMA ligation initiates the classical NF-κB1 pathway. These downstream signaling cascades promote cell survival and growth.