The Effect of Immunosuppressive Drugs on MDSCs in Transplantation

Table 1

MDSCs in transplantation.

Species	Years	Graft type	MDSC; location	Functional subsets	In vitro assay	Immune modulation	Mechanism of action	Ref.
Human	2018	Intestine	PBMC, intestinal mucosa	PMN-MDSC, M-MDSC, e-MDSC	Anti-CD3/28/MLR	Tac + P/HC + (MMF)	—	[28]
Human	2014	Kidney	PBMC	Total	No	Tac(CsA) + P + (MMF)	—	[27]
Human	2013	Kidney	PBMC	M-MDSC, e-MDSC	MLR	Tac + P + MMF	—	[46]
Human	2015	Allo-HSCT	WBC	M-MDSC, PMN-MDSC	Anti-CD3/28	Tac + methotrexate	iNOS/Arg1	[48]
Human	2015	Haplo-identical allo-HSCT	WBC	M-MDSC, PMN-MDSC, e-MDSC	—	CsA + MTX + MMF	—	[49]
Human	2013	Allo-HSCT	PBMC	M-MDSC	Anti-CD2/CD3/CD28-stimulating bead	Tac(CsA) + MTX	IDO	[46]
Mouse	2003	BMT	Spleen	Total	MLR	Irradiation	iNOS	[50]
Mouse	2004	BMT	Spleen	Total	MLR	Irradiation SHIP KO	—	[54]
Mouse	2011; 2012	Parental splenocyte to F1	Spleen	M-MDSC, PMN-MDSC	OT1 splenocytes with OVA/MLR	—	iNOS	[59]; [60]
Mouse	2018	Heart	Spleen	M-MDSC	Anti-CD3/28	Dex	iNOS	[90]
Mouse	2015	Heart	Graft	CD11b^+CD115^+Ly6C^lo, Ly6G^−CD169^+	MLR	Anti-CD40L	IL-10	[42]
Mouse	2010	Heart	Graft	M-MDSC	Anti-CD3/28	Anti-CD40L + DST	iNOS	[25]
Mouse	2015	Heart	Spleen	M-MDSC, PMN-MDSC	Anti-CD3/28	Rapa	iNOS	[30]
Mouse	2016	Skin	Spleen	M-MDSC (inhibition by rapa)	Anti-CD3/28	Rapa	iNOS	[29]
Mouse	2016	Skin	Spleen	Total	Anti-CD3/28	CsA	iNOS	[103]
Mouse	2014	Skin	Spleen	Total	MLR	Dex	iNOS	[89]
Mouse	2014	Skin	Spleen	Total	MLR	CsA	IDO	[102]
Mouse	2012	Heart	Graft	CD11b^+IDO^+	—	ECDI-fixed donor splenocyte + (rapa)	IDO	[44]
Rat	2008	Kidney	Blood	CD6^−NKRP-1^+CD80/86^+	MLR	Anti-CD28	iNOS	[31]
Mouse	2011	Heart	Graft	M-MDSC	No	IL-33	—	[36]
Mouse	2012	Skin	Spleen	Total	MLR	Smad3-KO	iNOS	[34]
Mouse	2008	Skin	Spleen	Total	Anti-CD3/28	ILT2-TG	Arg1	[33]

TAC: tacrolimus; CsA: cyclosporin A; P: prednisolone/prednisone; HC: hydrocortisone; MMF: mycophenolate mofetil; MTX: methotrexate; MP: methylprednisolone.