Cyanidin-3-glucoside Alleviates 4-Hydroxyhexenal-Induced NLRP3 Inflammasome Activation via JNK-c-Jun/AP-1 Pathway in Human Retinal Pigment Epithelial Cells

Figure 2

C3G reduced the production of IL-1β and IL-18 induced by HHE in RPE cells. C3Gs (50, 100 μM) were pretreated to the ARPE-19 cells for 2 h, and then HHE was challenged for 24 h in serum-free culture mediums. Cell culture mediums were collected, and the production of IL-1β (a) and IL-18 (b) is determined by ELISA. Bars with different letters are significantly different from each other (, ).

(a)

(b)