Journal of Immunology Research / 2018 / Article / Fig 2

Research Article

Combined Treatment with Zinc Aspartate and Intravenous Immunoglobulins (IVIGs) Ameliorates Experimental Autoimmune Encephalomyelitis (EAE)

Figure 2

Effects of therapeutic application of IVIG, zinc aspartate, and the combination of both on clinical signs of EAE. EAE was induced by immunization of SJL/J mice with PLP (p)139–151. Mice were treated i.p. from day 11 to day 15 with 10 mg/day IVIG (a), 30 μg/day zinc aspartate (b), or combination of 10 mg/day IVIG and 30 μg/day zinc aspartate (c). PBS treatment served as vehicle control. Treatment periods are indicated by the horizontal bar. Clinical disease scores were recorded daily. Data are presented as daily averages ± SEM of disease scores from 10 mice per treatment group. Significance is indicated as horizontal bar above the curves. indicates a significance of (Mann Whitney analysis).

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