miR-125a Suppresses TrxR1 Expression and Is Involved in H₂O₂-Induced Oxidative Stress in Endothelial Cells

Figure 1

Identification of the miR-125a target site in TRXR1 3-UTR. (a) Conservative sequences of the TRXR1 3-UTR shown in different species. The underlined part is the potential miR-125a binding site. (b) Schematic drawing of miR-125a binding with 3-UTR of TRXR1 and its mutant construct. (c) Relative luciferase activities of pGL3-UTR or pGL3-UTR-mut cotransfected with pmiR-ctrl, pmiR-125a, or miR-125a inhibitor in HEK293 cells. compared with pmiR-ctrl.

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