Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus

Table 1

Most potential 18 T-cell epitopes with interacting MHC-I alleles, epitope conservancy score, allergenicity, and toxicity.

Epitopes	Position	Antigenicity	MHC-I alleles	Conservancy	Allergenicity	Toxicity
TSSWGCEEY	1043–1051	0.9867	HLA-B27:20, HLA-C03:03, HLA-A32:07, HLA-A68:23, HLA-C12:03, HLA-B40:13, HLA-A32:15, HLA-C07:01, HLA-B15:02, HLA-B15:17, HLA-B35:01	100.00%	No	Yes
CSMCGLIHY	48–56	0.5400	HLA-B27:20, HLA-A68:23, HLA-C12:03, HLA-A32:07, HLA-B15:17, HLA-B40:13, HLA-B15:02, HLA-B15:01, HLA-C14:02, HLA-A32:15, HLA-B15:03, HLA-A30:02	100.00%	No	Yes
LAIDTGCLY	4–12	0.9551	HLA-C03:03, HLA-C12:03, HLA-B15:17, HLA-A68:23, HLA-B35:01, HLA-A32:07, HLA-A29:02, HLA-B15:01, HLA-B15:03, HLA-B15:02, HLA-B40:13	100.00%	Yes	Yes
SLIEICITL	34–42	0.9867	HLA-A02:11, HLA-A32:07, HLA-A02:12, HLA-A02:16, HLA-A02:01, HLA-A68:23, HLA-A02:02, HLA-A02:50, HLA-B27:20, HLA-C03:03, HLA-A02:03, HLA-A02:06, HLA-C12:03, HLA-A02:17, HLA-B15:02, HLA-C07:02, HLA-C14:02, HLA-A02:19, HLA-A32:15	76.19%	Yes	Yes
IIFALIITK	12–20	0.7267	HLA-C12:03, HLA-A11:01, HLA-A32:07, HLA-B40:13, HLA-A03:01, HLA-B27:20, HLA-A68:23, HLA-A68:01, HLA-A32:15, HLA-C03:03, HLA-A30:01	80.95%	Yes	Yes
LIHYRPGLK	53–61	1.7718	HLA-A32:07, HLA-B27:20, HLA-C12:03, HLA-C03:03, HLA-A68:23, HLA-A30:01, HLA-A03:01, HLA-B40:13, HLA-A32:15	80.95%	Yes	Yes
IFAAIIFAL	8–16	0.6140	HLA-C03:03, HLA-A02:50, HLA-B27:20, HLA-A02:02, HLA-A68:23, HLA-B40:13, HLA-A32:07, HLA-A02:11, HLA-A02:06, HLA-B15:02, HLA-C14:02, HLA-B42:01, HLA-C12:03, HLA-C07:02, HLA-A32:15, HLA-A68:02, HLA-A02:17	80.95%	Yes	Yes
NLPHVVPRY	25–33	0.6878	HLA-B27:20, HLA-A32:07, HLA-A68:23, HLA-C12:03, HLA-A02:17, HLA-B40:13, HLA-C14:02, HLA-C07:02, HLA-A32:15, HLA-B15:02	80.95%	Yes	Yes
NTIPAISGL	54–62	0.7847	HLA-A68:23, HLA-C03:03, HLA-A68:02, HLA-A02:50, HLA-A32:07, HLA-B15:02, HLA-B27:20, HLA-A26:02, HLA-C12:03, HLA-A02:17, HLA-A02:06, HLA-A69:01, HLA-C07:02, HLA-A32:15, HLA-B15:17	80.95%	Yes	Yes
VPRYHSIDV	30–38	1.5628	HLA-A68:23, HLA-B27:20, HLA-C12:03, HLA-A32:07, HLA-B07:02, HLA-B42:01	80.95%	No	Yes
IPAISGLGV	56–64	1.2054	HLA-A02:50, HLA-B27:20, HLA-A32:07, HLA-A68:23, HLA-C12:03, HLA-B42:01, HLA-B07:02, HLA-B40:13, HLA-A32:15	76.19%	Yes	Yes
YLKNHNIDL	26–34	1.7400	HLA-C12:03, HLA-B15:02, HLA-A02:50, HLA-A68:23, HLA-A32:07, HLA-C14:02, HLA-C03:03, HLA-B27:20, HLA-A02:12, HLA-A02:17, HLA-A02:03, HLA-C06:02, HLA-A32:15, HLA-B08:01, HLA-A02:02, HLA-C07:02	71.43%	Yes	Yes
YNVAWRTYL	19–27	0.4500	HLA-C03:03, HLA-A02:50, HLA-B27:20, HLA-B15:02, HLA-A68:23, HLA-A32:15, HLA-C12:03, HLA-C14:02, HLA-A32:07, HLA-A02:17	71.43%	No	Yes
LEPIIGDKL	54–62	0.4388	HLA-A02:17, HLA-A02:50, HLA-C12:03, HLA-A32:07, HLA-A68:23, HLA-B40:13, HLA-B27:20, HLA-B40:01, HLA-A32:15, HLA-B15:02	80.95%	No	Yes
CEEYGCLAI	1048–1056	1.6829	HLA-B27:20, HLA-C12:03, HLA-A32:07, HLA-B40:13, HLA-B40:01, HLA-A02:50, HLA-A68:23, HLA-C05:01, HLA-A32:15, HLA-C03:03	95.24%	Yes	Toxin
NSGPYNVAW	15–23	0.8498	HLA-B27:20, HLA-A32:07, HLA-C12:03, HLA-B40:13, HLA-A32:15, HLA-A68:23, HLA-C07:01, HLA-C03:03, HLA-B58:01, HLA-A02:50, HLA-B57:01	80.95%	No	Yes
RQHRGCIRF	43–51	1.0559	HLA-B27:20, HLA-B15:03, HLA-A32:07, HLA-B40:13, HLA-A68:23, HLA-B15:01, HLA-C12:03	71.43%	Yes	Toxin
AISGLGVGY	58–66	1.1548	HLA-A32:07, HLA-C12:03, HLA-A32:15, HLA-C03:03, HLA-A68:23, HLA-B27:20, HLA-B40:13, HLA-A30:02, HLA-B15:17	76.19%	No	Yes