|
| TNFAIP3 rs2230926 normal variant () | TNFAIP3 rs2230926 mutant variant () | value |
|
| Demographics | | | |
| Age (mean ± SD years) | 59.9 ± 13.7 | 56.7 ± 9.0 | 0.24 |
| Sex, female no. (%) | 280 (93) | 27 (100) | 0.39 |
| Age at SS diagnosis (mean ± SD, years) | 51.6 ± 13.5 | 45.2 ± 12.9 | 0.02 |
| Clinical characteristics | | | |
| Focus score (no. of foci/4 mm2) (mean ± SD) | 2.5 ± 2.3 | 3.1 ± 2.9 | 0.72 |
| Tarpley score | 2.2 ± 1.1 | 2.5 ± 1.1 | 0.30 |
| Erythrocyte sedimentation rate (ESR) (mm/h) | 39 ± 26 | 36 ± 27 | 0.77 |
| Dry mouth (%) | 278 (92.4) | 25 (96.2) | 0.70 |
| Dry eyes (%) | 275 (91.4) | 25 (96.2) | 0.71 |
| Salivary gland enlargement (SGE) (%) | 108 (35.9) | 6 (23.1) | 0.21 |
| Raynaud’s syndrome (%) | 85 (28.3) | 8 (30.8) | 0.82 |
| Lymphadenopathy (%) | 70 (23.3) | 6 (23.1) | 1.00 |
| Splenomegaly (%) | 11 (3.7) | 1 (3.8) | 1.00 |
| Parpable purpura (%) | 60 (19.9) | 8 (30.8) | 0.21 |
| Arthritis (%) | 79 (26.2) | 5 (19.2) | 0.49 |
| Arthralgias/myalgias (%) | 213 (70.8) | 19 (73.1) | 1.00 |
| Interstitial lung disease (%) | 24 (8.0) | 4 (16.0) | 0.25 |
| Liver involvement (autoimmune cholangitis) (%) | 15 (5.0) | 1 (3.8) | 1.00 |
| Kidney involvement (nephrocalcinosis) (%) | 4 (1.3) | 1 (3.8) | 0.34 |
| Lymphoma (%) | 82 (27.3) | 8 (30.8) | 0.82 |
| Laboratory characteristics | | | |
| Whole salivary flow (ml/15 min) (mean ± SD) | 1.6 ± 1.2 | 1.3 ± 1.3 | 0.43 |
| Presence of anti-Ro/SSA autoantibodies (%) | 223 (75.3) | 22 (88.0) | 0.22 |
| Presence of anti-La/SSB autoantibodies (%) | 123 (41.6) | 11 (44.0) | 0.84 |
| Positive rheumatoid factor (%) | 173 (62.9) | 14 (58.3) | 0.67 |
| Low-complement component 4 (C4) levels (<20 mg/dl), no (%) | 178 (60.5) | 15 (62.5) | 0.82 |
| Peripheral blood leucocyte count (mean ± SD per mm3) | 1629.5 ± 669.2 | 1566.0 ± 845.1 | 0.44 |
| Peripheral blood neutrophil count (mean ± SD per mm3) | 3464.7 ± 1705.8 | 2690.4 ± 628.3 | 0.009 |
| Peripheral blood monocyte count (mean ± SD per mm3) | 424.0 ± 228.0 | 345.9 ± 165.4 | 0.18 |
| White blood cell count (mean ± SD per mm3) | 5682.0 ± 1924.3 | 4915.8 ± 1125.7 | 0.04 |
| Gamma globulin levels (mean ± SD) | 33.9 ± 26.2 | 35.9 ± 27.1 | 0.72 |
| Lactate dehydrogenase (LDH) (mean ± SD) levels | 284.6 ± 122.1 | 518.2 ± 238.9 | 0.005 |
| β2-Microglobulin (mean ± SD) | 4.0 ± 2.6 | 5.6 ± 3.5 | 0.26 |
| Immunoglobulin IgA (mean ± SD) | 299.8 ± 146.7 | 403.3 ± 194.8 | 0.21 |
| Immunoglobulin IgG (mean ± SD) | 1683.5 ± 690.0 | 2790.0 ± 1656.7 | 0.08 |
| Immunoglobulin IgM (mean ± SD) | 183.1 ± 125.6 | 339.8 ± 308.1 | 0.02 |
| Presence of monoclonal band (%) | 34 (12.0) | 2 (8.0) | 0.75 |
| Cryoglobulins (%) | 35 (14.1) | 4 (25.0) | 0.27 |
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