Research Article
The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma
Table 3
Genotype distribution of the different polymorphisms and their association with MM susceptibility.
| | Polymorphisms | MM (%) | Controls (%) | OR (95% CI) | value |
| | IL-1β (rs16944) | | | | | | GG | 103 (29.0) | 92 (26.3) | 1 | | | AG | 162 (45.6) | 171 (48.9) | 1.182 (0.830, 1.684) | 0.355 | | AA | 90 (25.4) | 87 (24.9) | 1.082 (0.720, 1.626) | 0.704 | | Allele frequency | | | | | | G | 368 (51.8) | 355 (50.7) | 1 | | | A | 342 (48.2) | 345 (49.3) | 1.046 (0.849, 1.289) | 0.675 | | IL-18 (rs1946518) | | | | | | GG | 91 (25.6) | 93 (28.1) | 1 | | | GT | 185 (52.1) | 184 (45.8) | 0.973 (0.683, 1.386) | 0.88 | | TT | 79 (22.3) | 73 (26.0) | 0.904 (0.588, 1.390) | 0.646 | | Allele frequency | | | | | | G | 367 (51.7) | 370 (52.9) | 1 | | | A | 343 (48.3) | 330 (47.1) | 0.954 (0.774, 1.176) | 0.661 | | CARD8-C10X (rs2043211) | | | | | | AA | 89 (25.1) | 108 (30.9) | 0.69 (0.485, 0.982) | | | AT | 184 (51.8) | 154 (44.0) | 1.147 (1.006, 1.307) | 0.039 | | TT | 82 (23.1) | 88 (25.1) | 0.884 (0.586, 1.334) | 0.558 | | Allele frequency | | | | | | A | 362 (51.0) | 370 (52.9) | 1 | | | T | 348 (49.0) | 330 (47.1) | 0.928 (0.753, 1.143) | 0.482 | | NF-κB-94 ins/del (rs28362491) | | | | | | Ins/ins | 130 (36.6) | 109 (31.1) | 1 | | | Ins/del | 160 (45.1) | 175 (50) | 1.304 (0.935, 1.820) | 0.117 | | Del/del | 65 (18.3) | 66 (18.9) | 1.211 (0.79, 1.856) | 0.379 | | Allele frequency | | | | | | Ins | 420 (59.2) | 393 (56.1) | 1 | | | Del | 290 (40.8) | 307 (43.9) | 1.131 (0.916, 1.398) | 0.252 |
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