The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma

Table 4

The correlations of the genetic polymorphisms of the NLRP3 inflammasome with clinical features of MM patients.

	Age	Male : female	Type							DS			ISS			Bone damaged		Hemogram			BM myeloma
			IgG	IgA	Light chain (κ + λ)	IgD	IgE	IgM	Nonsecretory type	I	II	III	I	II	III	With	Without	WBC (×10^9/L)	Hemoglobin (g/L)	Platelet (×10^9/L)	Cell percentage (%)
CARD8-C10X (rs2043211)
AA	59 (25–80)	55 : 34	44	14	30	1	0	0	0	3	29	57	12	43	34	72	17	5.20 ± 0.28	88.95 ± 2.52	177.96 ± 8.96	34.04 ± 2.40
AT	59 (28–89)	107 : 77	78	39	59	5	1	1	1	8	73	35	25	79	80	153	31	5.71 ± 0.18	92.11 ± 1.87	183.97 ± 6.74	36.47 ± 1.78
TT	61 (25–84)	55 : 27	41	20	18	3	0	0	0	10	35	37	23	23	36	70	12	5.87 ± 0.28	93.03 ± 2.89	167.34 ± 8.26	36.99 ± 2.63
	0.175	0.524		0.18						0.016			0.01			0.437		0.022	0.331	0.598	0.41
	0.608	0.109		0.512						0.446			0.647			0.647		0.023	0.324	0.758	0.475
NF-κB-94 ind/del (rs28362491)
Ins/ins	60 (25–89)	77 : 53	61	28	36	3	0	1	0	8	48	74	25	51	54	103	27	6.7 ± 0.10	100.4 ± 0.23	219.61 ± 0.54	49.99 ± 0.37
Ins/del	60 (25–80)	98 : 62	69	37	48	6	1	0	0	2	65	93	18	61	81	135	25	6.76 ± 0.10	97.57 ± 0.21	222.37 ± 0.59	51.39 ± 0.30
Ins/del	58 (29–77)	42 : 23	33	9	23	0	0	0	0	1	24	40	7	33	25	57	8	6.69 ± 0.19	96.32 ± 0.33	215.13 ± 0.88	54.36 ± 0.40
	0.306	0.767		0.059						0.155			0.096			0.28		0.062	0.266	0.561	0.036
	0.352																	0.38	0.324	0.601	0.19
IL-1β (rs16944)
GG	60 (28–89)	66 : 37	46	18	35	4	0	0	0	3	36	64	14	39	50	88	15	6.77 ± 0.12	95.80 ± 0.26	220.61 ± 0.70	52.1 ± 0.39
AG	60 (25–84)		76	35	47	3	1	1	0	6	72	84	24	72	66	131	31	6.52 ± 0.09	101.35 ± 0.21	224.19 ± 0.52	50.55 ± 0.31
AA	59 (35–79)		41	21	25	2	0	0	0	4	29	57	12	34	44	76	14	7.04 ± 0.15	95.80 ± 0.25	211.43 ± 0.77	52.37 ± 0.36
	0.338	0.317		0.84						0.303			0.681			0.579		0.462	0.738	0.503	0.525
	0.995																	0.245	0.156	0.588	0.322
IL-18 (rs1946518)
GG	58 (29–91)	58 : 33	43	15	31	1	0	0	0	2	34	55	11	37	43	79	12	6.87 ± 0.13	95.12 ± 0.29	211.40 ± 0.38	52.62 ± 0.38
GT	60 (28–89)	107 : 78	85	37	55	7	1	1	0	7	68	110	28	73	84	154	31	6.57 ± 0.09	97.83 ± 0.19	218.92 ± 0.52	51.17 ± 0.28
TT	61.5 (25–79)	52 : 27	35	22	21	1	0	0	0	4	35	40	11	35	33	62	17	6.94 ± 0.15	103.15 ± 0.29	232.36 ± 0.85	51.12 ± 0.45
	0.399	0.399		0.422						0.604			0.908			0.351		0.395	0.03	0.951	0.496
	0.168																	0.429	0.249	0.839	0.987

, values of homozygous polymorphisms. , values of heterozygous polymorphisms.